An ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina. It may be either. Ameloblastic fibroma, is a mixed odontogenic tumor, which commonly affects young children under the age of 20 years, with the mandibular premolar-molar. ameloblastic fibroma in a 9-year-old boy has been presented along with a review of the literature. The tumor responded to conservative surgical treatment.

Author: Faeramar Doukazahn
Country: Belgium
Language: English (Spanish)
Genre: Love
Published (Last): 6 October 2015
Pages: 55
PDF File Size: 3.44 Mb
ePub File Size: 6.6 Mb
ISBN: 125-5-55746-920-3
Downloads: 74418
Price: Free* [*Free Regsitration Required]
Uploader: Meztijora

To receive news and publication updates for Case Reports in Pediatrics, enter your email address in the box below. This is an open access article distributed under the Creative Commons Ameloblstic Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Ameloblastic fibroma AF is an uncommon benign odontogenic tumour, with both epithelial and mesenchymal neoplastic ameloblasticc. It occurs most frequently in the posterior region of the mandible, while its occurrence in the fibroam is extremely rare. They are usually encountered in children, emphasizing it as an important diagnostic consideration. Herein, we report the first case of a bilateral ameloblaztic ameloblastic fibroma in a 2-year-old female child patient who presented with a chief complaint of swelling in the right mid facial region.

Ameloblastic fibromas AFs are a rare variety of benign odontogenic tumors composed of proliferating odontogenic epithelium embedded in a cellular ectomesenchymal tissue resembling dental papilla [ 1 ]. It was first described by Kruse in and later classified as a separate entity by Thoma and Goldman in [ 23 ].

Males show a slightly higher prediction than females M: AFs usually present with a well-defined amelkblastic or multilocular radiolucencies [ 7 ]. Ameolblastic lesions are predominantly asymptomatic, while the multilocular cases are often associated with jaw swelling [ 8 ]. However, most of the cases of AFs are encountered as an incidental finding [ 910 ] reiterating their radiographic significance in the differential diagnosis with entities such as dentigerous cyst, ameloblastoma, odontogenic keratocyst, and ameloblastic fibrosarcoma [ 11 ameloblatic, 12 ].

Microscopically AFs are composed of both the epithelial and connective tissue components; the later appears to recapitulate dental papilla made up of spindled and angular cells with delicate collagen, imparting a myxomatous appearance. The epithelial component is arranged in thin branching cords or small nests with scanty cytoplasm and basophilic nuclei, while stellate reticulum like cells are common in larger nests.

Mitoses are not a characteristic feature of ameloblastic fibroma [ 13 ].

In contrast to conventional ameloblastoma, the strands of AFs show double or triple layer of cuboidal cells. Numerous mitotic cells or any atypical mitotic figure if noticed suggests a malignant entity such as ameloblastic fibrosarcoma AFS in the differential diagnosis [ 1415 ].

AFs are usually treated conservatively by enucleation with curettage of the surrounding normal bone, while the aggressive lesions require a radical approach [ 16 ]. The present case reports signifies the importance of careful differential diagnosis of intrabony oral lesions with an atypical location. A 2-year-old female child patient visited the department of oral and maxillofacial surgery with a complaint of diffuse swelling in the right mid face since one year.

The swelling was progressive with gradual increase in size, consequently involving the contralateral side causing a swelling in the left mid facial region after 6 months. Both the swellings exhibited gradual increase in size with evidence of nasal blockage Figure 1.


On examination, amleoblastic swellings were diffuse extending on to the zygomatic arch, nontender with no secondary changes. Intraoral examination revealed a nontender, lobulated swelling which was firm to bony hard in consistency Figure 2. The swelling caused ameloblastif and buccal cortical expansion bilaterally and extended up to the pterygoid plates along with palatal bone thickening.

The overlying mucosa was intact.

Ameloblastic fibroma

Presently she is free from any recurrence. Computed tomography with 3D reconstruction was performed which revealed a hyperdense mass involving the labial and buccal cortex amelob,astic extending up to the pterygoid plates. The palatal bone also showed thickening with irregular surface Figure 3. Based on the clinical and roentgenographic amelobalstic, a presumptive preoperative diagnosis of odontogenic tumor was made.

The lesion was excised and curettage of the adjacent maxillary bone was performed under general anesthesia. The surgical specimen was then sent for histopathological analysis. Macroscopically, the specimen measured 3.

Ameloblastic fibroma Lalitha C H, Goyal S, Perka L, Kodangal S – J Indian Acad Oral Med Radiol

Microscopically, the lesion showed proliferation of strands of ameloblastic epithelial cells within a moderately cellular connective tissue stroma that closely simulates the dental papilla.

The epithelial islands, nests, and strands were composed of peripheral tall columnar hyperchromatic cells exhibiting reversal of polarity and loosely arranged central cells having angular to spindle shape. The mesenchymal component comprised evenly distributed plump ovoid and stellate cells in a matrix of loose myxoid tissue Figures 5 and 6.

Ameloblastic fibroma is a true-mixed neoplasm of odontogenic origin with both epithelial and mesenchymal tissues [ 4 ]. These neoplasms are noticed in young patients especially in the first two decades of life [ 17 ] and mandible is considered to be the most common site of occurrence than the maxilla by a factor 3. Incidence of Maxillary AF is believed to be uncommon by itself; its bilateral presentation is exceedingly rare. To the best of our knowledge, this is the first case presentation of a bilateral maxillary ameloblastic fibroma.

Males are more commonly affected than females, who are usually diagnosed between the first and second decades of life frequently presenting with a painless swelling of the jaw. The present patient was only 2 years old, fitting into the normal spectrum of ameloblastic fibroma, with the youngest age reported in a seven-week-old infant [ 19 ]. However, the clinical manifestations of AF are not characteristic and the tumor is frequently observed as an incidental finding in a routine radiographic examination [ 20 ].

There was a problem providing the content you requested

Normal eruption of the teeth in the affected area is usually altered with more than one-third of cases associated with an impacted tooth [ 21 ]. Radiographically they appear unilocular or multilocular with smooth well-demarcated borders [ 9 ] which are often misdiagnosed as dentigerous cyst when associated with an impacted tooth. Differential diagnosis of AF must also include entities such as ameloblastoma, odontogenic keratocyst, and ameloblastic fibrosarcoma [ 1213 ].

Cortical expansion of the affected bone is commonly observed [ 22 ] which was noted in the present case elucidating its true neoplastic nature. Microscopically the epithelial component occupies the mesenchymal stroma in various patterns like thin long strands, cords, nests, or islands.

Unlike the strands in ameloblastoma, the strands in AF exhibit double or triple layer of cuboidal cells [ 23 ]. The ectomesenchymal component is composed of typical plump fibroblasts with delicate collagen fibrils simulating the dental papilla [ 24 ]. The amount of cellularity differs from area to area within the same tumor and between tumors.


A narrow cell-free zone bordering the epithelium and juxta-epithelial hyalinization in the connective tissue, which ultrastructurally may represent exuberant basal lamina with or without resemblance to early stage of normal odontogenesis was noted [ 2526 ].

AFs are classified based on histology as granular cell type, where granular cells predominate in ectomesenchyme, papilliferous with marked proliferation of the epithelium [ 4 ], ameloblastoma in association with AF and cystic ameloblastoma [ 21 ]. If dentin or enamel were noticed, they are classified as an ameloblastic fibrodentinoma or an ameloblastic fibroodontoma, respectively. Cahn and Blum proposed the continuum concept by stating that these three mixed tumours were thought to represent various stages of tooth development [ 27 ].

There stands a controversy on this spectrum of lesions whether these should be classified as different entities or represent different stages of maturation of the same entity. The nature of AF still stands enigmatic, as there has been a long debate as to whether ameloblastic fibroma represents a hamartomous growth or is a true benign neoplasm. This controversy further attributes to the difficulties to differentiate between the histology of the neoplastic and the hamartomatous lesions with the histologic features of ameloblastic fibroma [ 4 ].

In recent times, it has been proposed that two variants of AF exist, namely, a neoplastic type with no inductive phenomenon and a hamartomatous type revealing inductive capabilities [ 21 ]. In addition to detecting the mitotic figures in the histology, immunohistochemical analysis using ki, PCNA, and p53 labelling indices would further aid in delineating AFS from AF [ 28 ].

A careful treatment planning is necessary considering their recurrence rate and ability to undergo malignant transformation. As it is difficult to differentiate a hamartomatous lesion from a neoplasm based merely on histology, age of the patient should be an important consideration while deciding the treatment plan.

Radical therapeutic methods should not be performed in the management of AFs in young patients [ 29 ]. Considering the age and high recurrence rate, a long-term follow-up is recommended, particularly in our case where both the siblings were diagnosed with AF necessitating future insight into the genetics. The authors declare that there is no conflict of interests regarding the publication of this paper.

Case Reports in Pediatrics. Indexed in Web of Science. Subscribe to Table of Contents Alerts. Table of Contents Alerts. Abstract Ameloblastic fibroma AF is an uncommon benign odontogenic tumour, with both epithelial and mesenchymal neoplastic proliferation.

Introduction Ameloblastic fibromas AFs are a rare variety of benign odontogenic tumors composed of proliferating odontogenic epithelium embedded in a cellular ectomesenchymal tissue resembling dental papilla [ 1 ]. Case Report A 2-year-old female child patient visited the department of oral and maxillofacial surgery with a complaint of diffuse swelling in the right mid face since one year.

Extraoral view showing mild swelling on the right and left mid face.

CT scan revealing hyperdense mass involving the labial cortex and pterygoid plates. Photomicrograph showing ameloblastic islands in a cellular connective tissue stroma. Photomicrograph showing tall ameooblastic ameloblasts with reversal of polarity.

View at Google Scholar A. View at Google Scholar P.

Ameloblastic fibroma

View at Google Scholar Y. World Health Organization Classification of Tumours: View at Google Scholar S. View at Google Scholar C. View at Google Scholar V.